Please note that this is a 10-month contract position.
- Role is 100% onsite
- Role is Oligonucleotide Analytics and/or Analytical Chemistry
- PhD degree required in a related field
- Performing quality control routines
- Characterizing molecules
- Must have at least 1 year of industry experience with PhD
Top Skills needed:
- Oligonucleotide analytics
- Analytical chemistry
- siRNA experience a MUST
- LCMS experience
Top Three Skills: Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughout analytical capabilities
Qualifications
Ph.D.. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required.
Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required.
Key Responsibilities:
30% Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
20% Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis
10% Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
20% Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
5% Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization
Support integrity confirmation requests (such as concentration) by assay development and biology teams
3% Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
5% Ensure the supply of laboratory consumables and reagents are in stock as needed
Maintain a high level of productivity in the laboratory setting.
2% Present data and reports on project status at individual, group, and departmental meetings.
Applicants must provide their phone number. Reference job number A4596.
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