Job Description

Please note that this is a 10-month contract position.

- Role is 100% onsite
- Role is Oligonucleotide Analytics and/or Analytical Chemistry
- PhD degree required in a related field
- Performing quality control routines
- Characterizing molecules
- Must have at least 1 year of industry experience with PhD
Top Skills needed:
- Oligonucleotide analytics
- Analytical chemistry
- siRNA experience a MUST
- LCMS experience

Top Three Skills: Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughout analytical capabilities

Qualifications
Ph.D.. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required.
Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required.

Key Responsibilities:
30% Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
20% Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis
10% Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
20% Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
5% Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization
Support integrity confirmation requests (such as concentration) by assay development and biology teams
3% Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
5% Ensure the supply of laboratory consumables and reagents are in stock as needed
Maintain a high level of productivity in the laboratory setting.
2% Present data and reports on project status at individual, group, and departmental meetings.

Applicants must provide their phone number. Reference job number A4596.

Employers have access to artificial intelligence language tools (“AI”) that help generate and enhance job descriptions and AI may have been used to create this description. The position description has been reviewed for accuracy and Dice believes it to correctly reflect the job opportunity.

• Dice Id: NETSO
• Position Id: A4596

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